The ability to determine the precise concentration and localization of a drug in target tissues is essential for preclinical research and development. Localization and concentration within the tissue are key parameters used to establish the appropriate dose required to provide adequate drug coverage. Current methods are only capable of determining the total drug concentration within a tissue sample. Therefore, the Seeker desires a new approach for measuring the spatial distribution of drug concentrations in target tissues.
This Theoretical Challenge requires only a written proposal.
Tissue homogenization is a standard procedure for processing samples prior to quantitative analysis of drug concentrations. Not only is compound recovery impacted by sample preparation, but it also is not possible to distinguish where in the tissue the drug predominates (e.g., intracellular vs. extracellular, or how deep the drug penetrated). Furthermore, the measurement of free vs. bound drug is complicated due to proteins released upon cell lysis and by non-specific binding to cellular debris. Therefore, the Seeker desires a new approach for measuring the spatial distribution of drug concentrations in target tissues.
This is a Theoretical Challenge that requires only a written proposal to be submitted. The Challenge award will be contingent upon theoretical evaluation of the proposal by the Seeker.
To receive an award, the Solvers will not have to transfer their exclusive IP rights to the Seeker. Instead, Solvers will grant to the Seeker a non-exclusive license to practice their solutions.
Submissions to this Challenge must be received by 11:59 PM (US Eastern Time) on April 1, 2017.
Late submissions will not be considered.
InnoCentive is the global innovation marketplace where creative minds solve some of the world's most important problems for cash awards up to $1 million. Commercial, governmental and humanitarian organizations engage with InnoCentive to solve problems that can impact humankind in areas ranging from the environment to medical advancements.
What is a Theoretical-Licensing Challenge?
An InnoCentive Theoretical Challenge builds upon an idea but is not yet a proof of concept. A solution to a Theoretical Challenge will solidify the Solver's concept with detailed descriptions, specifications and requirements necessary to bringing a good idea closer to becoming an actual product or service.
This Challenge is a Theoretical-Licensing Challenge, meaning that the Seeker is requesting non-exclusive rights to use the winning solution. By contrast, Theoretical-IP Transfer means that Solvers must relinquish all rights to the Intellectual Property (IP) for which they are awarded. For these forms of a Theoretical Challenge, Solvers that do not win retain the rights to their solution after the evaluation period is complete. The Seeker retains no rights to any IP not awarded.